Christina Applegate at the 2023 Screen Actors Guild awards. | Valerie Macon/AFP via Getty Images Christina Applegate, the actor who has been one of the most visible faces of multiple sclerosis since her 2021 diagnosis, made a stunning revelation this week: She does not have MS after all. And her doctors still don’t know what is causing her debilitating symptoms. “I’m back at square one,” Applegate told fellow actor Jamie Lynn Sigler, who does have MS, on Sigler’s podcast MeSsy. “I was not happy at all. Everybody else was so happy.” It is a harrowing predicament for Applegate, and hop...
What Christina Applegate’s misdiagnosis reveals about MS
HALO Newsroom
Oct 21, 2026 • 2 hours ago
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